منابع مشابه
Intrinsic cell factors that influence tumourigenicity in cancer stem cells - towards hallmarks of cancer stem cells
14 Since the discovery of tumour initiating cells (TICs) in solid tumours, studies 15 focussing on their role in cancer initiation and progression have abounded. The 16 biological interrogation of these cells continues to yield volumes of information on 17 their pro-tumourigenic behaviour, but actionable generalised conclusions have been 18 scarce. Further, new information suggesting a dependen...
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Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a remarkably consistent structure underlying high flux metabolism. The three prim...
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Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains a therapeutic challenge. Thus, understanding the biology of chemoresistance is of great importance to overcome this challenge and will conceivably benefit the surviva...
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malignant states into invasive cancers (Foulds, 1954). These observations have been rendered more con-sites, having suffered disruption through lesions as subtle as point mutations and as obvious as changes in Department of Biology Massachusetts Institute of Technology chromosome complement (e.g., Kinzler and Vogelstein, 1996). Transformation of cultured cells is itself a Cambridge, Massachuset...
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With the advent of next generation sequencing methods and progress in transcriptome analysis, it became obvious that the human genome contains much more than just protein-coding genes. In fact, up to 70% of our genome is transcribed into RNA that does not serve as templates for proteins. In this review, we focus on the emerging roles of these long non-coding RNAs (lncRNAs) in the field of tumor...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2016
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2016.152